Manystudies reported increased rate of morbidity and mortality in mentally ill
population. The increased rate of conditions like diabetes mellitus cardiovascular
disorders and obesity particularly abdominal adiposity and visceral abdominal
fat which is incriminated in diminished insulin sensitivity that leads to
diabetes. Many factors were attributed to these metabolic changes including the
life style issues like poor nutritional habits and reduced activity or even the
disease process itself. However, the antipsychotic medications have been
largely incriminated in this respect.
This stimulate some author to make extensive
reviewing and collect evidence for and against an association between glucose
or lipid deregulation and eight separate second-generation antipsychotics
currently available worldwide, specifically clozapine, olanzapine, risperidone,
quetiapine, zotepine, amisulpride, ziprasidone and aripiprazole. Reports of
adverse effects of antipsychotics on glucose and lipid metabolism have more
frequently associated with some antipsychotics specially clozapine and
olanzapine and less with quetiapine or risperidone. Other reports of limited
short or long terms weight gains with drugs like ziprasidone and aripiprazole.
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