https://www.austinpublishinggroup.com/tissue-engineering/
Diabeticfoot ulcers, venous leg ulcers, and pressure ulcers contribute to majority of
chronic wounds. The importance of improved wound healing measure is especially
well demonstrated by the healing problems in diabetes. It is estimated that
about 30% of all the costs for diabetes relates to wound care in USA. In
addition, 2.4-4.5 million people have been reported to have chronic lower
extremity ulcers in USA only. Pressure ulcers and leg ulcers, including venous
ulcers, cost as high as $8 billion annually in USA, and are a significant cause
of morbidity in aged population. Although a slow wound repair is a self-limiting
process and not a pathogenesis in itself, severe chronic wounds can also lead
to chronic inflammatory diseases, fibrosis, and cancer, comprising stifling
economic health care burdens.
Woundhealing in clinical settings relies primarily on enabling the natural course of
epidermal tissue regeneration. In many cases, the involved processes and the
progress of regeneration may be insufficient to save severely injured patients.
Especially difficult are various types of chronic wounds, with diabetic wounds
being the most severe type. Current conventional treatment of chronic wound
comprises mainly approaches with various types of dressings, bandages, and
antibiotics. Several skin substitutes have reached the market place for
second-line therapy of chronic ulcers, but they have not had the impact that
was predicted. In severe cases where the wounds do not heal, amputation is the
only treatment option that is available.
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