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Thursday 20 June 2019

HLA Incompatible Successful Renal Transplantation Across Bw4/Bw6 Alleles in Two Patients

                              https://www.austinpublishinggroup.com/transplantation-sciences/




HLAIncompatible (HLAI) renal transplantation with desensitization is being increasingly performed in Northern Ireland because it results in better quality of life and improved survival compared to long term maintenance dialysis. Risk stratification for potential recipients in the United Kingdom is performed according to British Society of Histocompatibility and Immunogenetics (BSHI) / British Transplant Society (BTS) guidelines, which involves comprehensive evaluation by a combination of Complement Dependent Cytotoxicity Cross-Match (CDCXM), Flowcytometry Cross-Match (FCXM) and Luminex Single Antigen Bead (SAB) assay, and correlation with sensitization history.


Transplantingsuccessfully across a broad specificity such as HLA- Bw4 or Bw6 may prove more difficult, because non–DSA reacting with Bw4 or Bw6 epitopes could have an additive effect and hence greater overall reactivity even if reactivity against the donor mismatched allele is low. In this paper the workup leading to successful outcome of two HLAI transplants performed in Belfast City Hospital is presented. Maintenance immunosuppression was with the triple drug regimen of Prednisolone, Mycophenolate Mofetil (MMF) and Tacrolimus.











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An Evaluation of the Role of fMRI in Patients with Lower Urinary Tract Dysfunction

                                                 https://www.austinpublishinggroup.com/urology/ Patientswith Lower Urinary Tr...