Protective Effect of Coenzyme Q10 in Mouse Testes Infected with Staphylococcus epidermidis

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The abundantpresence of saprophytes microorganisms in microbiological cultures has acquired interest in the study of infectious pathologies. The protective effect of coenzyme Q10 in mice testes infected with Staphylococcus epidermidis was evaluated. Sperm characteristics and testicular histology of male mice (NMRI) infected with S. epidermidis and infected and co-treated with coenzyme Q10 were studied. Sperm density, motility and morphology of epididymis, as well as testicular weight and histology were evaluated at 21 days post-treatment. Sperm abnormal forms and higher banana form and vacuolization in the seminiferous epithelium were observed in infected mice. The morphologic alterations were reduced after the treatment with coenzyme Q10 in co-trated group. Coenzyme Q10 may be an important therapeutic option in the reversal of sperm damage as potent antioxidant, in the restoration of reproductive tract epithelium and probably in infertility in mice infected with S. epidermidis.

Genital tractinfections have been associated to infertility in many couples. The most studied microorganisms responsible among the causes of infectious infertility are Chamydia trachomatis, Mycoplasma hominis, Ureaplasma urealyticum, Neisseria gonorrhoeae and Treponema pallidum among others. The impact of bacterial infection on seminal parameters are leukocyte production, with reduction of sperm density, normal forms and motility. The aforementioned microorganisms have been associated with reduction of seminal characteristics; however, no specific changes have been defined in semen with high concentrations of Gram positive cocci. The frequency of Coagulase-negative Staphylococci (CoNS) in seminal samples has broad frequency ranges. CoNS are considered saprophytes microorganisms of male urethra and are observed with higher frequency in semen of infertile men. A study showed associated the concentration of CoNS 104CFU/mL in semen with increased round cells (specially seminiferous epithelial cells instead leukocytes) and abnormal sperm forms (microcephalic). Another study showed that the same species of CoNS isolated in semen from infertile patients inoculated in testicles of rodents led to detachment of cells of the seminiferous epithelium and increase of compacted heads with smaller size and with lower acrosomal volume probably associated to oxidative stress.