Hydroquinone is benzene-1, 4-diol chemically or also known as quinol having the chemical formula C6H4(OH)2. It is topical agent used for treatment of certain skin conditions. In skin creams it is also used as de-pigmenter agent and antioxidant in the photography industry. Hydroquinone acts by inhibiting the melanin formation. Due to toxicological effects of hydroquinone it can cause dermatitis. In skin toning creams hydroquinone and some of its derivatives are present. So the determination of hydroquinone and its derivative in cosmetics is very important for the protection of human health. Tazarotene is member of the acetylenic class of retinoids. Tazarotene is chemically (ethyl 6-[2-(4, 4-dimethyl-3, 4-dihydro-2H-1-benzothiopyran-6-yl)-ethynyl]-pyridine-3-carboxylate). It is a third-generation topical retinoid. It is available in the form of cream, gel, or foam. Tazarotene is used for treatment of psoriasis, acne and photo damage skin.
Tazarotene is a prodrug which is converted to its active form by rapid de-esterification in humans and animals. Tazarotenic acid binds to all three members of the retinoic acid receptor (RAR) family: RARα, RARβ, and RARγ but shows relative selectivity for RARβ, and RARγ which may modify gene expression. The clinical significance of these findings is unknown.
Tazarotene plus hydroquinone is used in treatment of photo damaged facial skin. Literature review reveals that the efficacy of tazarotene is improved, when applied in combination with hydroquinone. A very few analytical methods are available for the estimation of drugs like tazarotene and hydroquinone in combination in pharmaceutical dosage formulation. The non-availability of analytical methods as on date for the concurrent analysis of multi-component formulations made it worthwhile to pursue the present research work. The developed method is also been validated as per ICH guidelines. The scope of developing and validating and analytical method is to ensure a suitable method for a particular analyte more specific, accurate and precise. The main objective for that is to improve the condition and parameters, which should be followed in the development and validation.
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