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Use of saturated fats cause LDL oxidation in systemic circulation and formation of
atherosclerosis and may develop coronary artery disease. In some cases, a blood
clot may totally block the blood supply to the heart muscle, causing heart
attack. If a blood vessel to the brain is blocked, usually from a blood clot,
an ischemic stroke can result. Hypolipidemic drugs can be used to treat
hyperlidemia, CAD, heart arrhythmias and cardiac arrest. Allopathic drugs used
to prevent or cure Hyperlipidemia include Statins, Fibrates, niacin and bile
acid binding resins. Gemfibrozil increases plasma HDL levels by stimulating their
synthesis. Increased transport (turnover) of HDL induced by gemfibrozil may be
significant in increasing tissue cholesterol removal in hyperlipidemic patients.
Furthermore, Fibrates treatment results in the formation of LDL with a higher
affinity for the LDL receptor, which are thus catabolized more rapidly. Nigella
sativa or kalonji contains conjugated linoleic acid, thymoquinone, melanthin,
nigilline, damascenine, and trans-anethole. Thymoquinone (TQ) extracted from
Nigella sativa (kalonji) inhibits iron-dependent microsomal lipid peroxidation.
Stimulation of polymorph nuclear leukocytes with thymoquinone works as
protector against damaging effects of free redicles generated biochemically in
human body.
Researchstudy design was single blind placebo-controlled, and was conducted at Jinnah
Hospital, Lahore from February 2012 to July 2012. Seventy five hyperlipidemic
patients were selected for research work. Written consent was taken from all
patients. Specific Performa was designed for the research work. Seventy-five
newly diagnosed primary hyperlipidemic patients were selected with age range
from 18 to 70 years. Exclusion criteria were hypothyroidism, diabetes mellitus,
alcohol addictive patients, peptic ulcer, any gastrointestinal upset, renal
impairment, and any hepatic or cardiac problem.
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