PEAis a natural occurring lipid belonging to the class of autacoids, we could
characterize these molecules as tissue hormones. Autacoids such as PEA may
become a new cornerstone in the treatment of chronic pain and inflammation. PEA
is not a registered drug, but it is widely available as supplement. I use PEA
in my patients suffering from neuropathic pain since 2010, and have done quite
some research on it. In the many hundreds of patients I treated, dose-limiting
and serious adverse events did not occur. This probably is related to the fact
that PEA is an endogenous lipid, produced on demand in the membranes of our
cells, and easily metabolized in the cell into metabolites which are than
recycled in those membranes. It also implies that dose-reduction in case of
liver- or kidney-insufficiency is not required. As more and more patients and
doctors become aware of this natural compound, a short introduction might serve
both groups.
Theuse of PEA as a painkiller in the first decade of this century was limited to
Italy and Spain only, because clinical papers in the English language were
missing. In Italy, the compound was used widely by neurologists and pain
specialists, due to the work of the Italian Nobel laureate professor Rita
Levi-Montalcini, who first clarified its mechanism of action as an
Anti-Inflammatory Agent.
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