Induction of Apoptosis in Human Lung Cancer Cells (A-549) by a Novel Nutrient Mixture via Upregulation of Caspase Enzymes

                               http://austinpublishinggroup.com/lung-cancer-research/

Worldwide,lung cancer is the most common cause of death from cancer and the incidence of lung cancer continues to increase. Although cigarette and tobacco smoking substantially increase the risk of developing lung cancer, the lifetime chance of developing lung cancer for a male is 1 in 15 and for females, the risk is slightly lower, 1 in 17. According to 2018 estimates of the American Cancer Society the 234,030 people may get a diagnosis of lung cancer in the United States and it may account for approximately 154,050 deaths. Small Cell Lung Cancer (SCLC) and Non Small Cell Lung Cancer (NSCLC) are the two major categories of lung cancer.

Only16% of the lung cancer cases are diagnosed at early stage. Most of the diagnoses occur when the cancer has already metastasized. More than 50% of patients die within one year of being diagnosed. Despite scientific advances surgery, chemotherapy, and radiation are still main modalities of treatment for lung cancer. Yet, both SCLS and NSCLC have poor prognosis with a 5-year survival rate of metastasized lung cancer has not improved more than 4% over several decades. There is therefore an urgent need to change the direction in cancer research and develop new, original and safer approaches.

being used as important treatment methods of cancers, due to their antitumor actions including induction of apoptosis. We have developed strategies to inhibit cancer development and its spread using a unique combination of naturally occurring nutrients. The antitumor Nutrient Mixture (NM) combination containing lysine, proline, ascorbic acid, and green tea extract has demonstrated anti-carcinogenic activity against a number of cancer cell lines.