info

Tuesday 22 January 2019

Colorectal Cancer; the Trend towards Earlier Age of Presentation

                             http://austinpublishinggroup.com/gastrointestinal-cancer/




Colorectal cancer (CRC) is the second leading cause of cancer related death in the UK. According to the office of national statistics in 2013, CRC is the eighth leading cause of death in 35-49 year olds and the fourth in 50-64 year olds. 11% of Colon and 18% of rectal cancers occur in patients below the age of 50 years.

Risk stratification, lifestyle modification, early screening and prophylactic surgery are helpful in patients with hereditary components to their disease. However little is available to diagnose the younger patient without a known predisposition to CRC. Literature has indicated that the incidence of CRC has been rising in people below the age of 40 years. Since the 1990s Bowel cancer incidence in the UK has increased for most age groups, but it has remained stable in people aged between 50-59 and 60-69. The largest increase in incidence has been in people aged between 25-49 European age specific incidence rates increased by 34% between 1993-1995 and 2012-2014.

CRC has been considered an older age disease often leading to delayed screening and referrals in younger patients with colonic symptoms. Average risk screening is now recommended in the United Kingdom to commence after the age of 55 years old, data had shown that there is an increasing trend towards younger patients developing CRC. This study aims to confirm whether this trend is reflected in local population and establish whether younger patients are presenting with more aggressive tumours.

It is well established that poorly differentiated histological features such as mucinous and signet ring features are common in younger patients and associated with a poorer prognosis in CRC. The increasing incidence is a younger working population will have significant impact on risk stratification and screening as well as a change in the traditional mind-set that CRC is a disease of the elderly.

No comments:

Post a Comment

An Evaluation of the Role of fMRI in Patients with Lower Urinary Tract Dysfunction

                                                 https://www.austinpublishinggroup.com/urology/ Patientswith Lower Urinary Tr...