Chemotherapyis the mainstay of treatment for advanced gastroesophageal cancer (AGC). There
is no consensus whether doublet or triplet chemotherapy is better. Hence our
study aimed to compare CAPOX (capecitabine and oxaliplatin) with EOX
(epirubicin, oxaliplatin plus capecitabine) as first line treatment for AGC.
From December 2012 to July 2014, total of 69 patients were randomly assigned;
35 to EOX arm (epirubicin 50 mg/m2 on day1,
capecitabine 625 mg/m2 twice daily
for 21 day and oxaliplatin 130 mg/m2 on day1 three
weekly for 8 cycle) and 34 to CAPOX arm (capecitabine 1000 mg/m2 twice daily for 14 days and oxaliplatin 130 mg/m2 on day 1 in a three weekly cycle for 8 cycle). Median
age at diagnosis was 55 years. The median number of chemotherapy cycle delivered
was 7.45% completed planned treatment. 63.8% patient needed dose modification
and 33.3% had treatment discontinuation due to grade 3/4 toxicity. Incidence of
grade 3/4 neutropenia was significantly more in EOX where as diarrhoea and
vomiting were more in CAPOX group. The ORR (overall response rate) was 63% in
the entire cohort and 54.5% and 71.4% in the CAPOX and EOX group respectively.
Median follow up was 15.2 month. Median OS (overall survival) was 8.1 and 10.3
months in the CAPOX and EOX groups respectively; p=0.298, however there was a
trend favouring PFS (progression free survival) in the EOX group (5.5 vs. 8.3
months in CAPOX and EOX respectively; p=0.06). No significant difference was
observed between the two regimens with respect to ORR, PFS and OS. Doublet
chemotherapy regimen (CAPOX) has similar efficacy as a triplet regimen (EOX),
however, with higher incidence of gastrointestinal toxicity.
AGC:Advanced Gastroesophageal Cancer; ALT: Alanine Transaminase; ALP: Alkaline
Phosphatise; AST: Aspartate Transaminase; CAPOX: Capecitabine and Oxaliplatin;
CR: Complete Response; EOX: Epirubicin, Oxaliplatin Plus Capecitabine; ECOG:
Eastern Co-Operative Group; GEJ: Gastro Esophageal Junction; HR: Hazard Ratio;
NCI-CTCAE: National Cancer Institute - Common Terminology Criteria for Adverse
Events; ORR: Overall Response Rate; OS: Overall Survival; PD: Progressive
Disease; PFS: Progression Free Survival; PR: Partial Response; RECIST: Response
Evaluation Criteria in Solid Tumors; SD: Stable Disease; TTP: Time To
Progression; ULN: Upper Limit of Normal.
Gastriccancer is the fifth most common cancer and third most common cause of death
worldwide. Despite recent advances in the diagnosis and treatment of gastric
cancer, many patients present with advanced disease and have poor survival.
According to data from the National Cancer Institute Surveillance, Epidemiology
and End Results (SEER) Program, the five-year survival for patients with
gastric cancer improved only modestly over the last 50 years, from 12 percent
in the years 1950 to 1954, 22 percent during the period 1996 to 2003. The
median survival for advanced gastric cancer is about four months without
treatment, and this extends up to one year with current treatment modalities.
Chemotherapy is the mainstay of treatment for advanced gastroesophageal cancer
(AGC). Initial trials used single agent drugs versus best supportive care.
Subsequent studies showed that combination chemotherapy result in superior
outcomes compared to monotherapy. Triple drug regimen is better than double
in the form of increased overall response rate (ORR) and time to progression
(TTP) but is associated with increased myelosuppression and infectious
complications. The recent REAL-2 trial has proven that capecitabine is
equivalent to 5-FU and oxaliplatin is equivalent to cisplatin with comparable
or even more response rate and survival. Combination therapies using cisplatin
and fluoropyrimidines with or without epirubicin or docetaxel have been widely
used as first-line treatments for AGC. There is no strong data whether doublet
or triplet chemotherapy is better, though ORR and TTP favors triplet regimen,
there is increased toxicity. We conducted a pilot study at our centre of
capecitabine and oxaliplatin (CAPOX) in locally advanced and metastatic
gastroesophageal cancer (unpublished data) that showed an ORR of 47.3%, and
median survival of 8 months, which are at par with current literature. With
this encouraging data we planned to conduct a randomized clinical study
comparing CAPOX with epirubicin, capecitabine and oxaliplatin (EOX) in AGC.
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