Objective: The aim is to study
the impact of antipsychotics on schizophrenic’s metabolic parameters in 6
months.
Methods: Blood glucose,
lipid profile, liver enzymes weight & waist circumference were assessed for
160 schizophrenia patients; at the beginning and after 6 months of continuous
use of antipsychotics. Patients with who used antipsychotics in the past 3 months
or have family history of diabetes or obesity were excluded.
Results: Except for white
blood count and High-Density Lipoproteins (HDL); all the studied parameters
showed significant elevation after 6 months of antipsychotic treatment. The
relation between the type of antipsychotic and the studied parameters showed
that the lipid profile was the only parameter of significance in relation to
drug type. Because not only the lipid profile but also other parameters
increased after six months we used analysis of covariance [ANCOVA] which showed
that the value of any studied parameters at the beginning of the study was
significantly determine the values at the end of the study, in addition, the
type of drug used in treatment is significantly influences the triglyceride
level and interaction of sex, drug used, and the history of drug treatment
could significantly determine the serum cholesterol and LDL levels.
Conclusion: The study
demonstrated elevated metabolic parameters in patients with schizophrenia
treated with antipsychotics. The burden of each antipsychotic was explored.
More research is needed to confirm our findings which are limited by the short
duration of the study, the fewer number of studied antipsychotics and sample
size
Keywords: Antipsychotics;
Schizophrenia; Metabolic
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