Mathematical analysis of medicinal plants for treating schizophrenia

Schizophrenia, a chronic and severe mental disorder, affects approximately 1% of the global population. Despite advances in pharmacotherapy, many patients experience suboptimal treatment responses or debilitating side effects. This has spurred interest in alternative treatments, including medicinal plants. This study aims to conduct a biostatistical analysis of medicinal plants used in treating schizophrenia, evaluating their efficacy and safety through rigorous statistical methods. And this study is dedicated to exploring the potential of traditional Chinese medicine in the treatment of schizophrenia. Specifically, a carefully formulated prescription consisting of 12g of Moutan Bark, 12g of Gardenia Fruit, 12g of Angelica Sinensis Root, 12g of Silk Tree Bark, 12g of Buddha’s Hand Fruit, 12g of Fermented Soybean, 6g of Coptis Root, 6g of Cinnamon Bark, 15g of Chinese Yam Rhizome, 6g of Amomum Fruit, 6g of Licorice Root, 10g of Solomonseal Rhizome, 10g of Green Citrus Peel, and 15g of Spiny Ziziphus Seed was used for treatment. This meticulously blended formula demonstrated remarkable efficacy in rigorous clinical trials. After a period of treatment, patients not only experienced effective alleviation of symptoms but also saw a significant improvement in their quality of life. This achievement not only validates the unique value of traditional Chinese medicine in treating schizophrenia but also offers new treatment options and hope for a wide range of patients.

For more information, visit the full study through below link.

Content Details:-

Corresponding author: Bin Zhao*

Full Length Article: Mathematical analysis of medicinal plants for treating schizophrenia

Journal: Journal of Community Medicine & Health Care

Disclaimer: This content is not owned or created by us. It has been sourced from the respective site, Austin Publishing Group, and is intended purely for study and educational purposes. All rights belong to the original authors and publishers.

Biostatistical Analysis on Incidence of Bacteria

This study investigated the incidence of bacteria and their antibiogram profile urine samples collected from students of the Hubei University of Technology, Wuhan, Hubei, China. A total of thirty (30) midstream urine samples were collected and bacteria in the samples were isolated using the spread plate method after which biochemical characterization was carried out. Escherichia coli, Pseudomonas spp, Klebsiella species, Salmonella species and Proteus species were the bacterial species isolated after which Kirby- Baurer disc diffusion antimicrobial assay was used to test their sensitivity against various antibiotics, such as Gentamycin, Cotrimozaxole, Ceftriaxone, Amoxyclay, Levofloxacin and Clavatin. From the study, Proteusspp shows zones of inhibition of (7mm for Cotrimozaxole), (5mm for Ceftriaxone), 5mm (for Gentmycin), (5mm), and 4mm (for Amoxyclav). E. coli 6.2 mm (Gentamycin), 3.6 mm (Levofloxacin), and 3.6 mm (Levofloxacin) zones of inhibition respectively. Gentamycin obtained 4.00mm, Levofloxacin 2.00mm and erythromycin 1.00 mm against Pseudomonas spp. Zones of inhibition were only observed on Clavatin (2.1 mm) for Salmonella species, while Klebsiella species was however, resistance to all the antibiotics tested. The highest sensitivity was observed in Cotrimozaxole which obtained a diameter of 7mm for Proteus spp., while the lowest zone was recorded for Pseudomonas species against Erythromycin with a diameter of 1 mm. This study revealed that most of the isolates were resistant to the antimicrobial agents the implication of antibacterial resistance as shown in the study. This study therefore recommends that proper hygiene should be observed before ingestion of food and water.

For more information, visit the full study through below link.

Content Details:-

Corresponding author: Bin Zhao*

Full Length Article: Biostatistical analysis on incidence of bacteria

Journal: Journal of Community Medicine & Health Care

Disclaimer: This content is not owned or created by us. It has been sourced from the respective site, Austin Publishing Group, and is intended purely for study and educational purposes. All rights belong to the original authors and publishers.

Enhancing Resistance to Sclerotinia Stem Rot in Brassica juncea Through Seed Priming with Bio-Control Agents

 

Brassica juncea (Indian mustard), a vital oilseed crop, is highly susceptible to Sclerotinia stem rot caused by Sclerotinia sclerotiorum, a pathogen that severely affects crop yield and quality. This study evaluated the effect of seed priming with bio-control agents, including Bacillus subtilis, Trichoderma viride, and their combination, on two varieties of B. juncea (RH30 and Varuna) under field conditions. Pathogen inoculation was performed at the reproductive stage, and morphological, biochemical, and yield-related parameters were assessed at 10 and 20 Days After Inoculation (DAI). The results demonstrated that the combined application of B. subtilis and T. viride significantly improved plant height, root and shoot biomass, and stem diameter. Biochemical analysis revealed enhanced levels of secondary metabolites such as flavonoids, phenolics, and ascorbate, along with increased activity of antioxidant enzymes, including Catalase (CAT), Polyphenol Oxidase (PPO), and Peroxidase (POX). These changes correlated with reduced disease symptoms, such as shorter stem lesion lengths, fewer sclerotia, and decreased stem breakage percentages. Additionally, yield attributes such as the number of siliquae per plant, seed size, and thousand-seed weight were markedly improved in plants treated with the bio-control agents. The combined treatment outperformed individual applications of B. subtilis or T. viride, demonstrating its superior efficacy in reducing disease severity and enhancing yield. This study highlights the potential of integrating bio-control agents into crop management practices to improve resistance against Sclerotinia stem rot and boost productivity in B. juncea. These findings offer a sustainable alternative to chemical methods for managing biotic stresses in oilseed crops.

For more information, visit the full study through below link.

Content Details:-

Corresponding author: Nita Lakra*

Full Length Article: Enhancing Resistance to Sclerotinia Stem Rot in Brassica juncea Through Seed Priming with Bio-Control Agents

Journal: Austin Journal of Plant Biology

Disclaimer: This content is not owned or created by us. It has been sourced from the respective site, Austin Publishing Group, and is intended purely for study and educational purposes. All rights belong to the original authors and publishers.

Prevalence of Ectoparasite Infestations in Cattle in Damot Sore District, Wolaita Zone, Southern Ethiopia

A cross-sectional study was carried out from February, 2024 to July, 2024 with the objectives of determining the prevalence of major ectoparasites of cattle associated with risk factors and to assess the prevalence of ectoparasite infestation in cattle in Damot sore district, Wolaita Zone, Southern Ethiopia. A total of 384 cattle (119 male and 265 female) were used to study the prevalence on live animals. The result obtained from live cattle demonstrates 52.3 % (201/384) of cattle were infested with one (12.4%) and more (39.9%) ectoparasites. Overall, eight genera of ectoparasites which belong to tick (47.7%), lice (4.4%) and mite (0.3%), were identified. Among the genera of the ticks Amblyomma (24.7%), Boophilus (12.8%), Hayalomma and Rhipicephalus (1%), respectively. Out of ticks the most prevalent genus was Amblyomma with a prevalence of 24.7% followed by genus Boophilus with a prevalence of 12.8% and finally genus Hayalomma and Rhipicephalus with a prevalence of 1.0 %, respectively. Statistically, significant variation (P<0.05) was observed in the prevalence of tick infestation on cattle of different age, sex and herd size groups. Among the genera of lice, the prevalence was mixed lice infestation such as Haematopinus, Linognathus and Damalina (4.4%) were identified. Significant variation (P<0.05) was observed in the prevalence of lice infestation of cattle among the age groups of the study animals. Demodex bovis (0.3%) was the only mite species recorded in this study. There was no statistical difference (P>0.05) between the prevalence of mange mite infestation with regard to age, sex and herd size variation. The overall infestation with ectoparasites was high in the females (53.58%) than males (49.57%). The present study revealed that the prevalence of ectoparasites in cattle in the study area and the major ectoparasites identified were tick, lice and mange mite, thus, improved management practice and wellcoordinated control interventions are required.

For more information, visit the full study through below link.

Content Details:-

Corresponding author: Ejigu Hizikel*

Full Length Article: Prevalence of Ectoparasite Infestations in Cattle inDamot Sore District, Wolaita Zone, Southern Ethiopia

Journal: Austin Journal of Veterinary Science & Animal Husbandry

Disclaimer: This content is not owned or created by us. It has been sourced from the respective site, Austin Publishing Group, and is intended purely for study and educational purposes. All rights belong to the original authors and publishers.

Review on Toll-Like Receptors and Their role in Immunity

Toll-like receptors (TLRs) are the best-characterized membrane-bound receptors in innate immune cells, including macrophages and dendritic cells. Upon recognition of specific ligands originating from pathogen and modified self-derived molecules, TLRs trigger intracellular signaling cascades that involve various adaptor proteins and enzymes, resulting in the generation of proinflammatory and antimicrobial responses through the activation of transcription factors such as nuclear factor-κB. TLR-dependent signaling pathways are tightly regulated during innate immune responses by a variety of negative regulators. Efforts to modulate these regulatory pathways and signaling molecules may result in the development of new therapeutic strategies through TLR-based therapy. This paper reviews the roles of TLRs in innate immunity and also emphasizes newly described regulation of TLR-dependent signaling pathways.

For more information, visit the full study through below link.

Content Details:-

Corresponding author: Ejigu Hizike*

Full Length Article: Review on Toll-Like Receptors and Their role in Immunity

Journal: Austin Journal of Veterinary Science & Animal Husbandry

Disclaimer: This content is not owned or created by us. It has been sourced from the respective site, Austin Publishing Group, and is intended purely for study and educational purposes. All rights belong to the original authors and publishers.

The Association of Body Mass Index with Malocclusion in Children - A Systematic Review & Meta-Analysis

Introduction: The relationship between Body Mass Index (BMI) and dental malocclusion remains uncertain. This systematic review aims to assess the link between BMI and malocclusion in children and adolescents. Sources of Data and Study Selection: Through electronic and manual searches up to August 2021, 1002 records were found, with 610 screened after removing duplicates. Eight studies were included in qualitative synthesis, and four in quantitative analysis. Malocclusion types, including crossbite, spacing, and crowding, were key review outcomes. The NIH quality assessment tool was used for bias assessment. This review encompassed eight studies involving 4128 children. Pooled analysis demonstrated significantly larger spacing in normal BMI children compared to those with low BMI. No significant difference was found in crossbite prevalence [1.33 (0.42, 4.25), p=0.63, I2=0%, p=0.85]. A quality assessment revealed four good-quality studies and the rest with poor/ fair quality. Conclusion: The impact of BMI on childhood malocclusion remains debated. Current research lacks consistent evidence linking BMI to malocclusion. To progress, future studies need standardized classifications and robust evaluation of confounding factors. This approach will strengthen understanding and guide effective interventions. Clinical Significance: Despite extensive research, the association between Body Mass Index (BMI) and dental malocclusion remains unclear, highlighting the complexity of this relationship. This systematic review suggests that normal BMI children tend to exhibit larger spacing between teeth compared to those with low BMI. Understanding such associations can aid in early detection and intervention strategies for malocclusion in children and adolescents.

For more information, visit the full study through below link.

Content Details:-

Corresponding author: Kusum Singal*

Full Length Article: The Association of Body Mass Index with Malocclusion in Children - A Systematic Review & Meta-Analysis

Journal: Austin Journal of Public Health and Epidemiology

Disclaimer: This content is not owned or created by us. It has been sourced from the respective site, Austin Publishing Group, and is intended purely for study and educational purposes. All rights belong to the original authors and publishers.

Ischaemic Monomelic Neuropathy and Compartment Syndrome: A Spectrum of Ischaemia

Ischaemic Monomelic Neuropathy (IMN) is a rare sequelae of arteriovenous fistula formation in the upper limb. It typically presents with sensory disturbance and represented ischaemic to peripheral nerves. A case of ischaemia following fistula revision is presented and ongoing ischaemic leading to acute compartment syndrome. The pathophysiology of IMN is unclear, however the ischaemic insult to the nerves must also affect the other structures in the forearm, including muscles, and should be recognised as spectrum of ischaemia. Progression to compartment syndrome is a significant risk with devastating consequences and should therefore be considered in any neurovascular disturbance following fistula formation.

For more information, visit the full study through below link.

Content Details:-

Corresponding author: Tom Challoner*

Full Length Article: Ischaemic Monomelic Neuropathy and CompartmentSyndrome: A Spectrum of Ischaemia

Journal: Austin Surgery Case Reports

Disclaimer: This content is not owned or created by us. It has been sourced from the respective site, Austin Publishing Group, and is intended purely for study and educational purposes. All rights belong to the original authors and publishers.

The Impact of Migration on The Eating Habits of Romanians

International migration has become an increasingly frequent phenomenon in recent decades, significantly influencing individuals’ eating behaviors. In the case of Romania, this phenomenon has led to major changes in the population’s diets, both through the emigration of Romanians to other European countries and the immigration of people from other cultures into Romania. This article examines the impact of migration on the eating habits of Romanians, addressing both the benefits and risks associated with these changes. By reviewing specialized literature and relevant case studies, the public health implications are highlighted, and recommendations for promoting a balanced diet are provided.

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Content Details:-

Corresponding author: Ionut Daniel Raducan*

Full Length Article: The Impact of Migration on The Eating Habits of Romanians

Journal: Austin Journal of Nutrition and Foodsciences

Disclaimer: This content is not owned or created by us. It has been sourced from the respective site, Austin Publishing Group, and is intended purely for study and educational purposes. All rights belong to the original authors and publishers.

Exploring Chest Disease Classification Methods Using X-ray Image Analysis

 

 

The World Health Organization has suffered from the limited diagnosis support systems and limited physicians. Especially in rural areas, almost all cases are handled by a single physician that is time consuming and tiring. Computer added diagnostic systems are being developed to solve this problem. The automated computer added diagnostic tools are of great significance for patient screening. The computer-aided detection based on Chest X-Ray Radiographs (CXR) play an important role in the diagnosis and treatment planning of the patients having lung diseases such as COVID-19, pneumonia etc. This review article presents a brief overview of all the available computer-aided systems to classify chest diseases using X-ray images. This review emphases the most common chest diseases such as Covid-19 and pneumonia along with different deep learning and machine learning techniques as available in the literature. This review paper can be useful for the researchers who are working in these areas for further improvements and advancements in the current technologies.

For more information, visit the full study through below link.

Content Details:-

Corresponding author: Jyoti Gupta*

Full Length Article: Exploring Chest Disease Classification Methods UsingX-ray Image Analysis

Journal: Austin Journal of Radiology

Disclaimer: This content is not owned or created by us. It has been sourced from the respective site, Austin Publishing Group, and is intended purely for study and educational purposes. All rights belong to the original authors and publishers.

Scapular Winging or Winged Scapula

 

Clinical Image Winged scapula results from insufficient dynamic fixation of the scapula to the thorax secondary to neuromuscular impairment. Winged scapula is rare but causes significant functional limitations. It is the consequence of neuromotor deficits in one of the scapulothoracic muscles that stabilize the scapula: the serratus anterior, trapezius, rhomboid major and minor, and levator scapulae. The two most common causes of winged scapula are; damage to the long thoracic nerve, which innervates the serratus anterior muscle and damage to the accessory nerve, which innervates the trapezius muscle. Electroneuromyography confirms the diagnosis.

For more information, visit the full study through below link.

Content Details:-

Corresponding author: Azriouil Ouahb*

Full Length Article: Scapular Winging or Winged Scapula

Journal: Austin Journal of Orthopedics & Rheumatology

Disclaimer: This content is not owned or created by us. It has been sourced from the respective site, Austin Publishing Group, and is intended purely for study and educational purposes. All rights belong to the original authors and publishers.

Huntington’s Disease – Something More Than Saint Vitus’s Dance.

The article on Huntington's Disease covers its genetic nature, pathophysiology, and clinical symptoms like motor and cognitive impairments. It highlights the importance of early diagnosis, genetic counseling, and treatment options, including therapies aimed at managing symptoms. It also emphasizes the need for support for both patients and their families.

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Content Details:-

Corresponding author: Muhammed Jasim Abdul*

Full Length Article: Huntington’s Disease – Something More Than Saint Vitus’s Dance.

Journal: Journal of Psychiatry & Mental Disorders

Disclaimer: This content is not owned or created by us. It has been sourced from the respective site, Austin Publishing Group, and is intended purely for study and educational purposes. All rights belong to the original authors and publishers.

The Therapeutic Relationship Between Healthcare Professionals and Hemodialysis Patients. Do the Health Care Professionals Put Themselves in Their Patients’ Shoes?

The study investigates the perception of empathy in the therapeutic relationship between healthcare professionals (HCPs) and hemodialysis (HD) patients. It reveals significant discrepancies between how HCPs perceive their empathy and how patients experience it. Nurses, nephrologists, and residents show varying degrees of empathy, with notable gaps in patients’ perceptions. The study emphasizes the importance of empathetic communication for improving patient outcomes, satisfaction, and adherence to treatment, especially in managing chronic conditions like CKD.

For a more details, check out the full article below link.

Content Details:-

Corresponding author: Savvatianopoulou M*

Full Length Article: The Therapeutic Relationship Between HealthcareProfessionals and Hemodialysis Patients. Do the HealthCare Professionals Put Themselves in Their Patients’Shoes?

Journal: Austin Journal of Nephrology and Hypertension

Disclaimer: This content is not owned or created by us. It has been sourced from the respective site, Austin Publishing Group, and is intended purely for study and educational purposes. All rights belong to the original authors and publishers.

Electrochemical Synthesis, Characterization, and Antimicrobial Activity of Nickel Nanowires

Nanotechnology is paving the way for groundbreaking advancements in medicine, particularly in combating antimicrobial resistance. Among these innovations, nickel nanowires have emerged as a promising tool with remarkable antibacterial properties. This blog delves into the electrochemical synthesis, characterization, and biological applications of nickel nanowires, as explored in a recent study.

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Key Highlights:

1. What are Nickel Nanowires?
   Nickel nanowires are nanoscale structures with high surface-to-volume ratios, magnetic properties, and biological activity, making them suitable for targeted antibacterial and potential anticancer therapies.

2. Synthesis and Characterization:

   • Synthesized using an electrochemical deposition method with anodic aluminum oxide templates.
   • Analyzed through SEM (Scanning Electron Microscopy), XRD (X-Ray Diffraction), and EDX (Energy Dispersive X-Ray Spectroscopy) for structural integrity and composition.

3. Antimicrobial Efficacy:

   • Nickel nanowires demonstrated potent antibacterial activity against gram-positive and gram-negative bacteria.
   • They created significant zones of inhibition, often surpassing traditional antibiotics.

4. Future Applications:

   • The study paves the way for targeted antimicrobial treatments that minimize the risk of resistance.
   • Potential use in cancer research to explore cytotoxic effects on malignant cell

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Conclusion:
Nickel nanowires represent a powerful innovation in the fight against bacterial infections, offering a sustainable alternative to traditional antibiotics. With further research, their application could revolutionize both medicine and global health.

For a more details into the findings and methodologies, check out the full article.

Content Details:-

Corresponding author: Masooma Jawad*

Full Length Article: Electrochemical Synthesis, Characterization, andAntimicrobial Activity of Nickel Nanowires

Journal: Austin Journal of Nanomedicine & Nanotechnology

Disclaimer: This content is not owned or created by us. It has been sourced from the respective site, Austin Publishing Group, and is intended purely for study and educational purposes. All rights belong to the original authors and publishers.

Bifurcation Analysis and Nonlinear Model Predictive Control of the Tri-Trophic Food Chain Model

 

This study delves into the intricate dynamics of a tri-trophic food chain model through bifurcation analysis and nonlinear model predictive control (NMPC). Using advanced computational tools like MATLAB’s MATCONT and Python's PYOMO, the research examines how bifurcation points (branch, limit, and Hopf) influence optimization and control strategies.

Key Highlights:

• Bifurcation Analysis: Identified key bifurcation points that lead to multiple steady-state solutions, crucial for understanding system stability.
• Nonlinear Control: Demonstrated that the presence of singularities aids NMPC calculations, achieving an optimal "Utopia solution."
• Tools Used: MATLAB (MATCONT) for bifurcation analysis and Python (PYOMO) for multi-objective optimization.

This work reaffirms the nonlinear complexity of food chain models and showcases the potential of bifurcation insights in enhancing predictive control techniques.

For a deeper dive into the findings and methodologies, check out the full article.

Content Details:-

Corresponding author: Lakshmi N Sridhar*

Full Length Article: Bifurcation Analysis and Nonlinear Model Predictive Control of the Tri-Trophic Food Chain Model

Journal: Austin Chemical Engineering

Disclaimer: This content is not owned or created by us. It has been sourced from the respective site, Austin Publishing Group, and is intended purely for study and educational purposes. All rights belong to the original authors and publishers.

Prevalence of Vitamin A and D Deficiencies in Children Under Five in South Asia and Africa: A Narrative Review

 

Micronutrient deficiencies, specifically in vitamins A and D, continue to pose significant public health challenges in South Asia and Africa. This narrative review highlights alarming prevalence rates among children under five in these regions.

Key Findings:

• Vitamin A Deficiency (VAD):

  • South Asia exhibits the highest burden, with Afghanistan (49.3%), Maldives (43.8%), and Pakistan (37%) reporting severe prevalence.
  • In Africa, Mozambique (71.2%), Zambia (56%), and Morocco (40.9%) lead in VAD cases.

• Vitamin D Deficiency (VDD):

  • Prevalence among children in South Asia reaches concerning levels, particularly in Sri Lanka (93%), Nepal (91%), and Afghanistan (81%).
  • Africa shows widespread deficiency, with some regions like Tunisia reporting rates as high as 89.66% in newborns.

 Note: Explore the full-length article at the link provided below.

Conclusion:

Urgent action is required to strengthen vitamin A supplementation programs and implement robust strategies to combat hidden hunger. Addressing these deficiencies is critical to improving health outcomes for the most vulnerable populations.

For more insights and in-depth data, read the full article.

Content Details:-

Corresponding author: : Abdul Jaleel

Full Length Article: Prevalence of Vitamin A and D Deficiencies in ChildrenUnder Five in South Asia and Africa: A Narrative Review

Journal: International Journal of Nutritional Sciences

Disclaimer: This content is not owned or created by us. It has been sourced from the respective site, Austin Publishing Group, and is intended purely for study and educational purposes. All rights belong to the original authors and publishers.

 

 

 

 

 

 

Real-World Efficacy of Faricimab in Treatment Resistant Neovascular Age-Related Macular Degeneration: A 12 Month Cohort Study

Faricimab, the first bispecific anti-VEGF agent, shows promise in managing treatment-resistant neovascular Age-Related Macular Degeneration (AMD). This retrospective 12-month study analyzed 191 eyes from 156 patients at Salisbury District Hospital, UK, focusing on anatomical and functional outcomes.

Note: Explore the full-length article at the link provided below.

Patients experienced significant central subfield thickness (CST) reduction, while Best-Corrected Visual Acuity (BCVA) remained stable. Faricimab allowed extended injection intervals, reducing treatment burdens for patients and caregivers.

These findings highlight Faricimab's potential as a viable alternative for persistent AMD cases. Long-term studies are necessary to assess the durability of these results.

Read the full study for deeper insights!

Content Details:-

Corresponding author: : Evans W, Department of Ophthalmology, Salisbury District Hospital, Odstock Road, Salisbury, UK.

Full Length Article: Real-World Efficacy of Faricimab in Treatment ResistantNeovascular Age-Related Macular Degeneration: A 12Month Cohort Study

Journal: Austin Ophthalmology

Disclaimer: This content is not owned or created by us. It has been sourced from the respective site, Austin Publishing Group, and is intended purely for study and educational purposes. All rights belong to the original authors and publishers.

Economic Analysis of the Juice and Concentrate Industry: (A Case Study of East and West Azerbaijan)

The juice and concentrate industry plays a crucial role in meeting the growing demand for natural beverages. A recent study focused on identifying and analyzing key bottlenecks affecting this industry in East and West Azerbaijan provinces, using surveys and advanced decision-making methods like DEMETEL and DANP.

Note: Explore the full-length article at the link provided below.

Key findings revealed that product costs, specialized human resources, inflation, packaging, and raw material expenses are the most significant challenges. Addressing these issues through strategic planning, improved management, and technological innovation is essential for optimizing industry operations and maintaining competitiveness in global markets.

This research emphasizes the importance of streamlining processes and adopting efficient strategies to tackle these bottlenecks, ensuring long-term sustainability and growth.

Read the full article to dive deeper into the solutions and implications for the juice and concentrate sector.

Content Details:-

Corresponding author: Rahim Dabbagh*; Babak Kouhileilan

Full Length Article: Economic Analysis of the Juice and Concentrate Industry: (A Case Study of East and West Azerbaijan)

Journal: Annals of Agricultural & Crop Sciences

Disclaimer: This content is not owned or created by us. It has been sourced from the respective site, Austin Publishing Group, and is intended purely for study and educational purposes. All rights belong to the original authors and publishers.

Children Theophylline Toxicity: Case Report

Introduction:-
Theophylline, a bronchodilator, has been widely used for respiratory conditions like asthma and COPD. Despite its declining use due to safer alternatives, theophylline toxicity remains a concern, particularly in pediatric cases, as it can lead to severe complications such as seizures, metabolic disorders, and cardiovascular instability.

Case Report:-
A 5-year-old girl presented with theophylline toxicity after ingesting 2000 mg, leading to symptoms like abdominal pain, vomiting, and a generalized seizure. Despite initial outpatient management, her condition worsened, requiring intensive care. The child experienced tachycardia, hypotension, metabolic disturbances, and cerebral edema. Management included seizure control with midazolam, hemodynamic stabilization, and treatment for infectious complications. The patient recovered without lasting neurological deficits.

 Note: Explore the full-length article at the link provided below.

Conclusion:-
This case highlights the critical importance of prompt and multidisciplinary management of theophylline toxicity. Preventive measures, such as keeping medications out of children’s reach, are essential. Early interventions, including activated charcoal and supportive care, can significantly improve outcomes in such cases.

Content Details:-

Corresponding author: Benani Mohame 

Full Length Article: Children Theophylline Toxicity: Case Report

Journal: Austin Journal of Clinical Case Reports

Disclaimer: This content is not owned or created by us. It has been sourced from the respective site, Austin Publishing Group, and is intended purely for study and educational purposes. All rights belong to the original authors and publishers.