Review on Toll-Like Receptors and Their role in Immunity

Toll-like receptors (TLRs) are the best-characterized membrane-bound receptors in innate immune cells, including macrophages and dendritic cells. Upon recognition of specific ligands originating from pathogen and modified self-derived molecules, TLRs trigger intracellular signaling cascades that involve various adaptor proteins and enzymes, resulting in the generation of proinflammatory and antimicrobial responses through the activation of transcription factors such as nuclear factor-κB. TLR-dependent signaling pathways are tightly regulated during innate immune responses by a variety of negative regulators. Efforts to modulate these regulatory pathways and signaling molecules may result in the development of new therapeutic strategies through TLR-based therapy. This paper reviews the roles of TLRs in innate immunity and also emphasizes newly described regulation of TLR-dependent signaling pathways.

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Content Details:-

Corresponding author: Ejigu Hizike*

Full Length Article: Review on Toll-Like Receptors and Their role in Immunity

Journal: Austin Journal of Veterinary Science & Animal Husbandry

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