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Monday, 10 September 2018

Nutritional Profile of Spirulina platensis, Chlorella vulgaris and Azolla pinnata to Novel Protein Source for Aquaculture Feed Formulation


                                   http://austinpublishinggroup.com/aquaculture-marine-biology/


Fisheriesand aquaculture make crucial contributions to the world’s well-being and prosperity. In the last five decades, world fish food supply has outpaced global population growth, and today fish constitutes an important source of nutritious food and animal protein for much of the world’s population. In addition, the sector provides livelihoods and income, both directly and indirectly, for a significant share of the world’s population. Aquaculture’s success and continuing growth have been more important for our world. The world’s population is projected to reach 9.3B in 2050 according to the medium variant of UN projections. Fish is a key source of protein, essential amino-acids and minerals, especially in low-income, food-deficit countries. Aquaculture growth has averaged 8% per year since the late 1970s (faster than human population growth), bringing fish production to a total of 142 Mt in 2008. About 115Mt are currently directed to human use, providing an estimated per capita supply of about 17 kg person-1yr -1, an all time high.

The aquaculture growth has relied heavily on fishmeal and fish oil. Fishmeal is an internationally traded, high protein powder, which results from the industrial processing of small pelagic fish (e.g. anchovy, sardine, capelin, and herring). It is a key component of the aqua feed of salmon, trout, shrimp and other farmed marine species supplying essential amino acids, fatty acids and other micronutrients. Due to these properties, FM has become one of the primary components of commercial feed formulations. The demand for FM in aquatic feeds has been estimated to account for 31% to 42.5% of total world FM production. However, as a result of a decreasing supply of fishery byproducts and concerns over its quality, the aquaculture industry is now actively investigating alternatives nutrient sources. In the last two decades, although worldwide FM production remained at a relatively stable level, it still could not match the rapid worldwide development of aquaculture. The cost of FM increased constantly, which caused the price of commercial feed increase sharply. Thus, there is an urgent need to find alternative protein sources to make up for the shortage of FM and to secure a stable supply for commercial diets. Now a day, the considerable interest and research have been focused on the developing unicellular organisms such as yeast, molds, bacteria, microalgae and fungi as additives to aquaculture feeds.

Pulmonary Artery Sling: Anesthetic Challenges and Fast Track Technique





This is the first case of pulmonaryartery (PA) sling with tracheal stenosis to be reported in our center, Ain shams University hospital for the past 10 years, although our experience with cardio-thoracic surgery started over 60 years, we still don’t have reported cases and formulated anesthetic technique for PA sling procedures. We are fully aware that this pathology is very rare and it could account for less than 1% of congenital heart diseases candidates for corrective surgeries. Vascular rings are a nightmare for most of anesthesiologists as it is may affect the trachea causing tracheal stenosis and obstruction. The exact pathology of pulmonary artery sling is that the left pulmonary artery (LPA) arises from the distal origin of the right pulmonary artery (RPA), the LPA runs in a tortuous retro-tracheal location causing posterior compression on the trachea in the pre-carinal level.

2 years old, 10kilograms, male infant presented with marked airway obstruction and repeated chest infection not responding to medical treatment, investigations revealed a PA sling with tracheal stenosis measuring 4.0mm (Figure 2), with complicated functional atrial septal defect (ASD). Surgical team decided to go for a definitive repair of the sling and relief the compression on cardio-pulmonary bypass. Airway management was crucial for fear of tracheomalacia, preoperative fiberoptic bronchoscope was irrelevant, chest radiographs revealed right lung consolidations and tracheal stenosis just above the carina as mentioned, but there were no signs or symptoms of severe airway obstruction or stridor, chest examination revealed bilateral inspiratory rhonchi and coarse Crepitations, sepsis markers as c-reactive protein were negative and no signs of active infection was present, Echocardiography revealed ASD measuring 4.9mm with normal pulmonary artery pressure besides the PA sling, other laboratory profile were unremarkable, so we decided to start inhalational induction and insert an armored tube size 4mm ID without difficulty and ventilated on a pressure support mode, P insp 12 and applying 5 Cm H20 PEEP, lung recruitment maneuver was needed after induction by ET tube suctioning, bronchodilators, and Dexamesthasone 2mg iv, ETCO2 is maintained 25-30 mmHg throughout the operation.

Friday, 7 September 2018

Testing the Experts



In absence ofreliable models and prevailing data paucity expert judgments constitute a valuable alternative for land degradation assessments. Yet, these qualitative expert opinions are branded as subjective and non-reproducible as tests for consistency are missing and qualitative classes remain difficult to interpret. This communication summarizes formal procedures to test expert judgment for consistency, reproducibility while correlation with quantitative data makes qualitative judgments interpretable.

Devastating effectsof land degradation on natural resource quality, landscape heritages and ecology have far reaching consequences for current and future human well-being. The cry for action to curb the catastrophic effects of land degradation at national scale, the level where most decisions on land use take place, seem, therefore, justified. Yet, assessing degradation processes at larger scale is not an easy task. Despite vast resources spent on development of degradation models there are hitherto no reliable quantitative assessment methods available to prioritize interventions at regional or national scale. The main reason is the chaotic and highly unpredictable nature of the degradation process that is influenced by many factors, some of which are poorly understood. Indeed absence of dense and long term monitoring networks impede explanation of the year-to-year variation of land degradation in its geographical dependence of natural resources and land use. Instead land degradation assessments increasingly resort on qualitative expert opinions that express the state of land degradation in ordered qualitative classes information that is easy to collect and inexpensive. Yet, principal criticism on uniformity, reproducibility and interpretability permeate these assessments and this communication aims to address these concerns and by introducing tests for consistency, formalizing the relationship between expert judgments and explanatory variables and quantifying boundaries of the qualitative assessments.

Thursday, 6 September 2018

Implementation of a Solution for the Remote Monitoring of Subjects Affected of Metabolic Diseases: The Metabolink Project

                              http://austinpublishinggroup.com/aging-research/


Diabetes represents one of most serious public health disease. The aim of the Metabolink project was to develop a smart solution for elderly people with diabetes and obesity, in order to promote a healthier style of life, improve diabetic control trying to reduce overall cost for the community.It consists of an app for Smartphone linked to a system and a process of data collection based on bi dimensional barcode (qr code) and NFC-tag technologies.
The system was accepted by all the patients and they learned efficaciously in a few hours to use it. Unfortunately we observed a drop-out of about 50% in the first month. Patients remaining in the study refer a slight improvement in the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q) and General Satisfaction Questionnaire (GSQ) and they decided to continue to use it after the end of the follow-up.
The diabetes represents one of most serious public health disease for the planet. The WHO estimated about 60 million of subjects are affected in Europe. In Italy the rough prevalence is 5.8%. The prevalence of disease in the next years will grow both as a result of the aging of the population and to the increase of the risk factors such as overweight and obesity, sedentary lifestyle and lack of proper nutrition education. Milestone studies have shown that an intensive glycemic treatment significantly reduces microvascular complications with a moderate positive long-term effect on macrovascular complications. The health care systems are called to face this disease that it has not only direct cost linked to pharmacological and complications treatment but also an indirect significant social cost. It is therefore essential for the diabetic patient to carry out a continuous and accurate monitoring of clinically relevant parameters (as blood glucose, blood pressure) and to follow a health life style in order to reduce disease complications permitting to live better maintaining independence for much more longer time. Moreover the majority of patients with diabetes is older and frequently present significant comorbidity making the integrated management of the disease more complex. The aim of the Metabolink project was to develop a smart solution for elderly people with diabetes and obesity, in order to promote a healthier style of life, improve diabetic control (glcaemic control, blood pressure, adherence to a specific diet and treatment) trying to reduce overall cost for the community. The approval of the study for experiments using human subjects was obtained from the local Ethics Committees on human experimentation. Written informed consent for research was obtained from each patient or from relatives/legal guardian in the case of critically disabled demented patients prior to participation in the study.

Wednesday, 5 September 2018

A Program of Medical Students as Teaching Assistants in an Anatomy Course: Effectiveness and Improvement


                                               http://austinpublishinggroup.com/anatomy/


Modern medical education emphasizes non-technical competency. Programs in early medical education that enhance interprofessional communication and teamwork introduce students to their future team members in the current landscape of healthcare. While skills-based interprofessional programs have been encouraged, few have implemented similar measures for interprofessional teaching. Recommendations exist for development of such interprofessional programs in the pre-clinical setting and acquisition of shared competencies to facilitate patient care. Research has indicated a positive impact of early teaching experiences on the development of core teaching competencies, but data on medical student teaching in an interprofessional setting are limited. Only one other institution has reported using medical students to teach physician assistant students in a first year anatomy course. These studies, however, do not address areas in which teaching assistants can improve across a variety of modalities, such as coordination of shared dissection time, baseline knowledge of anatomy with admission of the lack there of, and attentiveness to the specific needs of the student teams. Although reviews have described positive benefits to student teachers in areas of academic learning and professionalism the student learners’ perspective is often left unaddressed. In determining areas wanting for improvement, it follows that student feedback and student perception of teaching assistants may be the most constructive input.
The medical student Teaching Assistant (TA) program was established in 2014 at Sidney Kimmel Medical College and has been shown to contribute to core competency development in medical students. Here, we aim to continue analysis of this program with further insight on the impact teaching assistants have on Physician Assistant (PA) students. Attempts to unmask previously undiscovered and unaddressed areas for improvement with specific questionnaire items may allow for a more targeted approach to improving the experiences of both parties.

Monday, 3 September 2018

New Multi Wavelength Method for the Estimation of Tazarotene and Hydroquinone in Gel Formulation





Hydroquinone is benzene-1, 4-diol chemically or also known as quinol having the chemical formula C6H4(OH)2. It is topical agent used for treatment of certain skin conditions. In skin creams it is also used as de-pigmenter agent and antioxidant in the photography industry. Hydroquinone acts by inhibiting the melanin formation. Due to toxicological effects of hydroquinone it can cause dermatitis. In skin toning creams hydroquinone and some of its derivatives are present. So the determination of hydroquinone and its derivative in cosmetics is very important for the protection of human health. Tazarotene is member of the acetylenic class of retinoids. Tazarotene is chemically (ethyl 6-[2-(4, 4-dimethyl-3, 4-dihydro-2H-1-benzothiopyran-6-yl)-ethynyl]-pyridine-3-carboxylate). It is a third-generation topical retinoid. It is available in the form of cream, gel, or foam. Tazarotene is used for treatment of psoriasis, acne and photo damage skin.

Tazarotene is a prodrug which is converted to its active form by rapid de-esterification in humans and animals. Tazarotenic acid binds to all three members of the retinoic acid receptor (RAR) family: RARα, RARβ, and RARγ but shows relative selectivity for RARβ, and RARγ which may modify gene expression. The clinical significance of these findings is unknown.


Tazarotene plus hydroquinone is used in treatment of photo damaged facial skin. Literature review reveals that the efficacy of tazarotene is improved, when applied in combination with hydroquinone. A very few analytical methods are available for the estimation of drugs like tazarotene and hydroquinone in combination in pharmaceutical dosage formulation. The non-availability of analytical methods as on date for the concurrent analysis of multi-component formulations made it worthwhile to pursue the present research work. The developed method is also been validated as per ICH guidelines. The scope of developing and validating and analytical method is to ensure a suitable method for a particular analyte more specific, accurate and precise. The main objective for that is to improve the condition and parameters, which should be followed in the development and validation.

Jackfruit Allergy – An Increasing Exotic Problem Linked to the Oral Allergy Syndrome


                                                     http://austinpublishinggroup.com/allergy/


Jackfruit (Artocarpus heterophyllus), otherwise known as breadfruit, is a member of the mulberry family. Allergic reactivity to jackfruit has only rarely been reported. We describe five cases of jackfruit allergy in people of Asian origin evident several years after their migration to the UK. All the patients had a long history of Seasonal Allergic Rhinitis (SAR) and allergic reactivity to fresh fruit such as apples and peaches as part of an Oral Allergy Syndrome (OAS). Skin testing with the raw jackfruit was confirmatory but blood tests in all but two of the cases were negative.

Outline details of five patients with jackfruit allergy are provided below. The critical details of the symptoms surrounding allergic reaction to jackfruit, symptoms indicative of Oral Allergy Syndrome (OAS) and the blood and skin prick testing results are all provided.

A 49-year-old woman of Indian origin developed features of a systemic allergic reaction within 2 minutes of consuming roughly 10gms of fresh jackfruit. Emergency treatment with anti-histamines, hydrocortisone and adrenaline was used by the ambulance crew and she had improved significantly on reaching hospital. Despite an allergic reaction to fresh apple 6 years previously, she was still able to tolerate commercial long life apple juice and there were no other fruit sensitivities. She had moderate asthma and there was no indication of latex or kiwi fruit allergy.



TB Treatment Success Rate in Ethiopia: Key Findings & Challenges

Tuberculosis (TB) remains a major global health issue , infecting one-third of the world's population . Despite efforts, Ethiopia's...