Between 1965 and 1974, the NBRL was located at the Chelsea Naval Hospital which was renamed the Boston Naval Hospital. Two books were written to report the studies performed and the data reported during this period: Blood Banking and the Use of Frozen Blood Products and Hypovolemic Anemia of Trauma: The Missing Blood Syndrome. In addition a monograph published in 2006 reported the 30-year experience at the NBRL to study the survival and function of fresh, liquid preserved, and frozen baboon RBC, platelets, and plasma clotting proteins: The survival and function of baboon red blood cells, platelets and plasma proteins: a review of the experience from 1972 to 2002 at the Naval Blood Research Laboratory, Boston, Massachusetts. In the 65 peer-reviewed NBRL publications reported in the monograph, the bleeding time measurement was shown to be an accurate method to assess the hemostatic function of fresh, liquid preserved and cryopreserved baboon red blood cells, platelets, and plasma clotting proteins.
In 2007, the monograph: Non-surgical bleeding diathesis in anemic thrombocytopenic patients: Role of temperature, RBC, platelets, and plasma clotting proteins was published. This monograph reports that nonsurgical blood loss correlated to the bleeding time in normal volunteers and in patients. The bleeding time measurement was affected by the temperature and the function of the RBC, platelets, and plasma clotting proteins. The monograph summarized 45 peer-reviewed NBRL publications which measured the bleeding time in normal volunteers and patients to assess the hemostatic effect of the red blood cells, platelets, and plasma proteins to reduce the bleeding time and reduce the nonsurgical blood loss. The monograph identified that the temperature had a significant effect on the bleeding time. Hypothermia produced a significant increase in the bleeding time and increase in nonsurgical blood loss and increase in temperature reduced the bleeding time and reduced the nonsurgical blood loss.
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