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Monday 9 July 2018

Cardiotoxicity Proceeding Stem Cell Transplantation





HSCT is a process in which there is intravenous infusion of progenitor cells and hematopoietic stem cells to revive normal hematopoiesis. When stem cells are taken from patient’s own body, this is called autologous HSCT. When stem cells are taken from identical twin of the patient, this is called syngeneic HSCT. When stem cells are taken from body other than patient (siblings), this is called allogeneic HSCT.

During the procedure, autologous or allogeneic stem cells are infused into veins in order to restore normal hematopoietic function. Evaluation of health status: It involves following steps (complete history and physical exam, Evaluation of your psychological and emotional strengths, HLA tissue typing, Blood tests, such as a complete blood count, blood chemistries, and screening for viruses like hepatitis B, CMV, and HIV, CT (computed tomography) scan or MRI (magnetic resonance imaging), ECG or echocardiogram, chest x-ray and PFTs (pulmonary function tests).

Conditioning treatment: It is also known as bone marrow preparation, is treatment with high-dose chemo and/or radiation therapy. It’s the first step in the transplant process and usually it takes a couple of weeks. Infusion of stem cells: Infusion of cells is done through central venous catheter, much like a blood transfusion. If frozen stem cells are taken, patient might get some drugs before the stem cells are given. These drugs are used to prevent the reaction to the preservatives that are used when freezing the cells.

Stem cell transplantation is curative in a number of otherwise fatal hematological diseases.
In an autologous transplant, stem cells are collected from the patient themselves, harvested, frozen and stored, then given back to the patient after intensive therapy. An autologous stem cell transplant is different from an allogeneic stem cell transplant, which uses stem cells from a matching donor.

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