info

Thursday 5 July 2018

ADAM10 is Elevated in Microscopic Polyangiitis and is Involved in Inflammation

                                      http://austinpublishinggroup.com/austin-rheumatology/

                                               


Background: A disintegrin and metalloproteinase (ADAM) 10 has been reported to be involved in certain autoimmune diseases, such as rheumatoid arthritis. In this study, we demonstrate that ADAM10, which is a member of the ADAM family, is expressed in angiitis, and we examine its relationship to this condition using clinical data.

Materials and Methods: The ADAM10 levels in serum from microscopic polyangiitis (MPA) patients and healthy controls were measured using enzyme-linked immunosorbent assay. The clinical data were collected from Showa University cohort data. The relationship between the ADAM10 level in the sera and the clinical data was evaluated using Spearman’s rank correlation.

Results: No significant differences were observed in the mean age or gender ratio between the MPA patients and the healthy controls. The ADAM10 level in MPA serum (n=10) was significantly elevated compared with that in healthy control serum (n=7) (450 ± 44 pg/ml and 85 ± 33 pg/ml, respectively). The ADAM10 level in MPA serum was also significantly negatively correlated with myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) titer, but not with the C-reactive protein level.

Discussion: ADAM10 is elevated in MPA patients and might be involved in their inflammation. On the other hand, ADAM10 is negatively correlated with MPO-ANCA. These results indicate that ADAM10 might be involved in inflammation other than MPO-ANCA.

A disintegrin and metalloproteinases (ADAMs) are a family of proteinases that are known to be involved in ectodomain cleavage and in the regulation of the intramembrane proteolysis of transmembrane proteins. ADAM10 and 17 are the major proteases that cleave some membrane-bound proteins, and have extensive overlap with and compensate for several substrates, including epidermal growth factor receptor ligands, tumor necrosis factor (TNF), TNF receptor, and interleukin (IL)-6 receptor. ADAM17 is also known as TNF-α converting enzyme (TACE) and was identified as the primary protease responsible for the proteolytic processing of TNF-α. ADAM17 is expressed in numerous human tumors and is associated with invasion and metastasis. ADAM10 is also involved in the shedding of many substrates that play roles in cancer progression, allergic responses and inflammatory diseases. We previously showed that ADAM10 is involved in angiogenesis and the inflammation associated with rheumatoid arthritis (RA). However, the role of ADAM10 in other autoimmune diseases has not been examined. Here, we describe the expression and possible implications of ADAM10 in angiitis.

No comments:

Post a Comment

An Evaluation of the Role of fMRI in Patients with Lower Urinary Tract Dysfunction

                                                 https://www.austinpublishinggroup.com/urology/ Patientswith Lower Urinary Tr...