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Thursday 11 January 2018

Evolution of the Incidence, Treatment, and Mortality of Cervical Cancer in Patients Treated at Miguel Servet University Hospital of Zaragoza


Cervical cancer is the second most frequent gynecological tumor worldwide. The main reason for this frequency is not practicing adequate cytological screening. We performed a descriptive study of patients with invasive cervical cancer treated at our center from January 2003 through December 2015. In this period, 316 patients were diagnosed with cervical cancer. The mean age was 54.39 ± 16.20 years, with a range of 19 to 90 years and a mode of 49 years. A total of 77.8% of the patients were Spanish and 22.2% were foreign. The initial treatment was surgical in 57.9% of the patients and radio-chemotherapy in 42.1%. The most frequent tumoral stage was IIB followed by IB1. The most common histological type was squamous carcinoma (61.3%), followed by adenocarcinoma (22.6%). Most of the patients, 64.2%, did not experience a relapse and overall survival was 64.9%. Notably, 86.30% of study subjects had not had an appropriate cervical cancer screening test.
After breast cancer, cervical cancer is the type of cancer with the highest incidence and mortality worldwide [1]. As many as 83% of cases of cervical cancer are diagnosed in developing countries, whereas it is less frequent in developed countries [2]. In Europe, cervical cancer ranks fourth among the most frequent types of cancer, and it is the seventh most common cause of mortality [3]. Although Spain is one of the European countries with a lowest incidence, two women die every day from cervical cancer despite the successful screening programs in place. The primary goal of this study was to determine the incidence, therapy, relapse rate, and mortality of patients diagnosed with infiltrating cervical cancer treated in our hospital in the last 13 years to assess the evolution of these factors over time.
Secondary objectives included assessing the origin of referral, tumor stage, and more frequent histological types, and determine the efficacy of screening programs. The study was performed in the Miguel de Servet University Hospital (HUMS), which is located in Zaragoza, the fifth largest city of Spain. HUMS is a third-level hospital serving a population of 530,510 people. It is also the reference hospital for gynecologic oncology of the Autonomous Community of Aragon. Aragon has a population of 1.277.471 inhabitants, which accounts for 2.85% of the Spanish population. The total population of Zaragoza is 917,288 (71% of the population of Aragon). We conducted a retrospective review of patients diagnosed with cervical cancer and treated in our hospital from January 2003 to December 2015. During the study period, a total of 316 women were diagnosed with cervical cancer.

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