Objectives: This study explores the clinical value of surgical resection combined with Hyperthermic Intraperitoneal Chemotherapy (HIPEC) under elevated Intra-Abdominal Pressure (IAP) in treating Spontaneous Rupture of Hepatocellular Carcinoma (srHCC). Methods: The clinical data of 79 patients admitted to the Affiliated Hospital of Xuzhou Medical University, the Second Affiliated Hospital of Nanjing Medical University and the Affiliated Hospital of Soochow University from January 1, 2018 to January 1, 2023 for surgical treatment of ruptured hepatocellular carcinoma with hemorrhage were analyzed. Patients who received surgical resection combined with intraperitoneal hemoperfusion chemotherapy were included in the experimental group, which was further divided into Low-HIPEC group and High-HIPEC group based on the perfusion pressure. The control group (n-HIPEC group) included those who performed surgery alone. The clinical data, postoperative hospitalization time, complications, Postoperative Tumor-free Survival (PFS), Overall Survival (OS), and independent risk factors affecting prognosis were compared between the three groups. Results: There was no statistically significant difference in the number of complications and laboratory tests (before the treatment) between the three groups (P>0.05). The PFS was greater in the experimental group compared to the control group, with the High-HIPEC group exhibiting the highest rate, and this difference was statistically significant (P<0.05). However, the OS did not show a statistically significant difference among the three groups (P>0.05). Conclusions: High IAP in HIPEC is well tolerated and significantly improves patient prognosis.
Content Details:-
Corresponding author: Jian Niu**
Journal: Austin Surgical Oncology
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