Arsenic is a metalloid that can be toxic
to humans and other living organisms, occurs naturally and anthropogenically
throughout the world at varying concentrations, including concentrations of
concern in soil or groundwater. Presently, in Bihar (India) 18 districts are
affected with arsenic poisoning in ground water causing lots of health hazards
among the population. This arsenic intoxication has caused lots of health
related problems in the population. The present study has been designed, to
study the ameliorative effect of Murraya Koenigii on sodium arsenite induced
toxicity in Swiss albino mice. The treatment groups received sodium
arseniteorally at the dose of 3mgkg-1 body weight daily for 4 weeks followed by
administration of Murraya Koenigii 350mgkg-1 body weight daily by gavage
method for 4& 6 weeks. Their biochemical levels like liver and kidney
function tests were assayed and were observed with elevated levels.
Furthermore, their free radical assessment like lipid peroxidation levels were
assayed which was found to be many folds higher. But, after administration of
aqueous extract of Murraya Koenigii, there was significant amelioration
in the biochemical and lipid peroxidation levels. Therefore, it is evident from
the present study that Murraya Koenigii possesses antidote effects and
acts effectively against arsenic induced toxicity.
Arsenic is ametalloid that can be toxic to humans and other living organisms, occurs
naturally and anthropogenically throughout the world at varying concentrations,
including concentrations of concern in soil or groundwater. Acute arsenic
exposure harms human health in many ways including the development of
malignancies, severe gastrointestinal toxicities, diabetes, cardiac arrhythmias,
cancer and death. Natural sources such as volcanic action, erosion of rocks,
and forest fires introduce arsenic into the environment (EPA, 2001).
Anthropogenic sources include arsenic added to the soil plant system as
insecticides, herbicides, pesticides, livestock dips and wood preservatives. It
is estimated that more than 200 million people worldwide are chronically
exposed to dangerous levels of arsenic which leads to several diseases, including
various types of cancer. Arsenical exposure through drinking water is common in
many areas of the world. Metabolic disorders, hypertrophy of adrenal glands and
anaemia inhibition of the activity of steroidogenic enzymes and reduction in
the weight of the testis and accessory sex organs are associated with exposure
to arsenicals. Presently, in Bihar, 18 districts are highly affected with
arsenic poisoning. The groundwater contamination by arsenic is maximum 1928ppb in
Buxar district of Bihar.
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