Fibromyalgia is a complex neuroendocrine pain condition, but it
is not incurable. Unfortunately, it cannot be cured simply by managing the
symptoms with medication or picking one endocrine item to correct. It is
important to discern how the patient came to develop fibromyalgia if you want
the patient to actually recover.
As a group, Fibromyalgia patients seem all to have very similar
neuroendocrine profiles when they reach the pain clinic. They have symptoms of
low thyroid and high but normal TSH. Poor digestion and irritable bowel are
common. Abnormal levels of gonadal hormones, low progesterone, testosterone,
FSH and LH are characteristic.
As a group, Fibromyalgia patients have low levels of branch
chain amino acids that interfere with proper serotonin and dopamine production
and may contribute to abnormal thyroid hormone receptor structure. Pain is
amplified in the thalamus instead of being suppressed there.
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